If you are left-handed then you will benefit from having a mouse that fits your hand (many are designed specifically for the right hand). You will also benefit from swapping over the left and right buttons. This is because your index finger is usually the easiest finger to move in isolation from the other fingers.
Windows 10
Open the Windows 10 Start Menu and type “mouse”. Select Mouse & Touchpad settings or Change you mouse settings.
In the window that appears you can change the primary mouse button from left to right. Don’t forget from now on you’ll need to use your right button where you would have used your left button. If you leave it like this it can be very confusing for anyone that tries to use your computer!
That was easy.
Windows XP, Vista and Windows 7
Swapping the mouse buttons Windows is also easy.

Click on your Start button and select Control Panel.

Inside the Control Panel, locate the ‘Mouse’ icon and double-click it to launch it.
If you struggle with double-clicking then you can click on it once to highlight it, and then press the enter key to open it.

The Mouse Properties dialog window should pop up. Click on the ‘Left-handed’ text under ‘Button configuration’.
Click OK and the buttons will have swapped over. It will remain like this unless someone changes it back.

Just before we finish up – SwapMouseButtons is a great little program that swaps the mouse buttons over in a flash simply by pressing CTRL+F12.
You can download this program for free from my downloads page.